I think that the US is looking very tapped out, or at least suspect, and I believe that good fun can be had elsewhere in the world.
For me, the best choice is clear: Tokyo. Think 50's atomic monsters, go-go bars, giant robots, aliens, psychics, all sorts of Japanese weird cinema, science bases hidden under the sea. The potentials here are atomic. Best of all, you can put all the writing in Japanese and make Americans learn bits of a foreign language. Your character who is illiterate really can't read. You get to see how Japan fared against China, survived the war, and went on to become it's own unique ruin.
That game? I'd pay full price for that game.